Cancer and the Science of Denial

August 11, 2017

By Dr. Lawrence Broxmeyer MD

Broxmeyer L. Cancer and the Science of Denial. J Tumor Med Prev 2017;1(3):1-26

Cancer and the Science of Denial. From: J OF TUMOR MED & PREV 1(3): 555563

  • Lawrence  Broxmeyer, MD
    Uploaded by
    L. Broxmeyer, MD

Submitted: May 24, 2017  Published: July 14, 2017

The word ‘cancer’ is of Latin derivation and means crab. By the turn of the 20th Century organized medicine had come to the conclusion that it was not a matter of whether infectious disease caused cancer, but which one. Then, in 1910, certain American medical powers did a 180-degree rotation –abruptly deciding that cancer was not caused by a microbe. This flew in the face of over two hundred years of research in which a cancer germ had been discovered and rediscovered. Of all the infectious possibilities for cancer, unquestionably the one class of microbes that has been long recognized to most consistently mimic and imitate ‘cancer’ at both clinical and tissue levels were the mycobacteria of the family Actinomycetales of which tuberculosis and leprosy are premier examples. The association of TB with carcinoma was initially described about 200 years ago by Bayle who considered the lung malignancy ‘cavitation cancereuse’ to merely be one of the various types of tuberculosis. Ever since, almost as if in reflex to the obvious –the potential association between TB and subsequent development of cancer has drawn active investigation.


1. Falagas ME, Kouranos VD, Athanassa Z, Kopterides P (2010) Tuberculosis and malignancy. Q J M 103(7): 461-487.
2. Yu YH, Liao CC, Hsu WH, Chen HJ, Liao WC, et al. (2011) Increased lung cancer risk among patients with pulmonary tuberculosis: a population cohort study. J Thorac Oncol 6(1): 32-37.
3. Zhang S, Guang-ling Z, Yan-sheng T (2009) Detection of Mycobacterium tuberculosis L-form infection in tissues of lung carcinoma. Chin J Public Health 25: 1317-1318.
4. Chauhan A, Madiraju MV, Fol M, Lofton H, Maloney E, et al. (2006) Mycobacterium tuberculosis Cells Growing in Macrophages Are Filamentous and Deficient in FtsZ Rings. J Bacteriol 188(5): 1856-1865.
5. World Health Organization, Global Tuberculosis Report (2016) Geneva: World Health Organization, USA.
6. Yang B, Tian Y, Cui X, Zhang W, Ma Y, et al. (2013) Detection of Mycobacterium tuberculosis L-forms and MPB64 in breast cancer tissues. The Journal of Practical Medicine 29(15): 2552-2555.
7. KJ Ryanand, CG Ray (2004) Sherris Medical Microbiology, 4th (edn), McGraw-Hill, USA.
8. Guliang H, Tefu L (1999) Mycobacterium tuberculosis L-forms. Microbial Ecology in Health and Disease 10: 129-133.
9. Kakkar S, Kapila K, Singh MK, Verma K (2000) Tuberculosis of the breast. A cytomorphologic study. Acta Cytol 44(3): 292-296.
10. Puneet, Satyendra KT, Ragini R, Sanjay Singh, Guptav SK, et al. (2005) Breast Tuberculosis: Still Common In India. The Internet Journal of Tropical Medicine 2(2).
11. Vagholkar K, Gopinathan I, Pandey S, Maurya I (2014) Tuberculosis of the Breast (Case Report and Review of Literature). The Internet Journal of Surgery 31(1).
12. Liu Y, Lin TF (1996) Studies on morphology and electron-micrographic analysis of M tuberculosis filamentous L-forms. Chinese J Micro Boil Immunobiol 16(Suppl 2): 49.
13. Dai YH, Lin TF, Huang GL (1996) A serial study on mycobacteria L-forms. Zhongguo Fanglao Zazhi 45-46.
14. Shleeva MO, Salina EG, Kaprel’iants AS (2010) Dormant form of Mycobacterium tuberculosis. Mikrobiologiia 79(1): 3-15.
15. Marcova N, Slavchev G, Michailova L (2012) Unique biological properties of Mycobacterium tuberculosis L-form variants: impact for survival under stress. Int Microbiol 15(2): 61-68.
16. Warthin AS (1899) The Coexistence of Carcinoma and Tuberculosis of the Mammary Gland. Am J M Sci 118: 25-35.
17. Rosen PP (1979) Multinucleated mammary stromal giant cells-a benign lesion that simulates invasive carcinoma. Cancer 44(4): 1305-1308.
18. Hektoen L (1898) The fate of the giant cells in healing tuberculous tissue, as observed in a case of healing tuberculous meningitis. J Exp Med 3(1): 21-52.
19. Iakimenko LN (1976) Changes in the Mitotic Regime of a Cell Culture under the Influence of Sensitins. Biull Eksp Biol Med 81(2): 237-239.
20. Golubchik IS, Iakimenko LN, Lazovskaya AL (1972) Effect of Tuberculin on the Mitotic Regime in Cell Cultures. Biull Eksp Biol Med 73(5): 105-107.
21. Rao VV, Gupta EV, Thomas IM (1990) Chromosome Damage in Untreated Tuberculosis Patients. Tubercle 71(3): 169-172.
22. Much H, Uber Die Granuläre, Nach Ziehl Nicht Färbbare Form des Tuberkulosevirus. Beit Z Klin Tuberk 8th (edn), 85(1907): 85-97.
23. Kahn MC (1929) The Developmental Cycle of the Tubercle Bacillus as Revealed by Single Cell Cultures. Am Rev Tuberc 20(1929): 150.
24. Ribbert H (1894) Beitrage zur Histogenese des Carcinoms. Arch Pathol. Anat U Physiol Virchow’s 135: 433-469.
25. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, et al. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 266(5192): 1865-1869.
26. Huang YQ, Li JJ, Kaplan MH, Poiesz B, Katabira E, et al. (1995) Human herpesvirus-like nucleic acid in various forms of Kaposi’s sarcoma. Lancet 345(8952): 759-761.
27. Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, et al. (2007) Small Molecule Enhancers of Rapamycin-Induced TOR Inhibition Promote Autophagy, Reduce Toxicity in Huntington’s Disease Models and Enhance Killing of Mycobacteria by Macrophages. Autophagy 3(6): 620-622.
28. Jang WS, Kim S, Podder B, Jyoti A, Nam KW, et al. (2015) Anti-Mycobacterial Activity of Tamoxifen against Drug-Resistant and Intra-Macrophage Mycobacterium tuberculosis. J Microbiol Biotechnol 25(6): 946-950.
29. Ertem E, Yüce K, Karakartal G, Onal O, Yüce G (1990) The antituberculous effect of bleomycin. J Antimicrob Chemother 26(6): 862-863.
30. Gajadeera C, Willby MJ, Green KD, Shaul P, Fridman M, et al. (2015) Antimycobacterial activity of DNA intercalator inhibitors of Mycobacterium tuberculosis primase DnaG. J Antibiot (Tokyo) 68(3): 153-157.
31. Forbes L, Ebsworth-Mojica K, Di Done L, Li S-G, Freundlich JS, et al. (2015) A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis. PLoS One 10(6): e0129234.
32. Subramanyam CSV, Ahuja JM, Sapra ML (1975) Miliary tuberculosis simulating acute myeloid leukemia- review of literature and report of a case. Ind J Tub 22(4): 136-141.
33. Ananthan S, Faaleolea ER, Goldman RC, Hobrath JV, Kwong CD, et al. (2009) High throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) 89(5): 334-353.
34. Greenstein RJ, Su L, Shahidi A, Brown WD, Clifford A, et al. (2014) Unanticipated Mycobacterium tuberculosis complex culture inhibition by immune modulators, immune suppressants, a growth enhancer, and Vitamins A and D: clinical implications. Int J Infect Dis 26: 37-43.
35. Zhang L, Zheng Y, Callahan B, Belfort M, Liu Y (2011) Cisplatin Inhibits Protein Splicing, Suggesting Inteins as Therapeutic Targets in Mycobacteria. J Biol Chem 286(2): 1277-1282.
36. Batista AA, Back DF, Lang ES, Ellena J, Lemos S, et al. (2010) Palladium (II) complexes with thiosemicarbazones. Syntheses, characterization and cytotoxicity against breast cancer cells and Anti-Mycobacterium tuberculosis activity. J Braz Chem Soc 21(7): 1177-1186.
37. Datta M, Via LE, Kamoun WS, Liu C, Chen W, et al. (2015) Antivascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery. Proc Natl Acad Sci U S A 112(6): 1827-1832.
38. Lamb R, Ozsvari B, Lisanti CL, Tanowitz HB, Howell A, et al. (2015) Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease. Onco target 6(7): 4569-4584.
39. Watt B, Rayner A, Harris G (1996) Comparative activity of azithromycin against clinical isolates of mycobacteria. J Antimicrob Chemother 38(3): 539-542.
40. Walker NF, Clark SO, Oni T, Andreu N, Tezera L, et al. (2012) Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases. Am J Respir Crit Care Med 185(9): 989-997.
41. Pang H, Li G, Wan L, Jiang Y, Liu H, et al. (2015) In vitro drug susceptibility of 40 international reference rapidly growing mycobacteria to 20 antimicrobial agents. Int J Clin Exp Med 8(9): 15423-15431.
42. Shu X, Gao YT, Linet MS, Brinton LA, Gao RN, et al. (1987) Chloramphenicol use and childhood leukemia in Shanghai. Lancet 2(8565): 934-937.
43. Yuan ZR, Shi Y (2008) Chloramphenicol induces abnormal differentiation and inhibits apoptosis in activated T cells. Cancer Res 68(12): 4875-4881.
44. Smith RM, Joslyn DA, Gruhzit 0M, McLean IW, Penner MA, et al. (1948)Chloromycetin: biological studies. J Bacteriol 55: 425.
45. Youmans GP, Youmans AS, Osborne RR (1948) Tuberculostatic action of Chloromycetin in vitro and in vivo. Proc. Soc. Exp Biol & Med 67: 426.
46. Rattan R, Ali Fehmi R, Munkarah A (2012) Metformin: an emerging new therapeutic option for targeting cancer stem cells and metastasis. J Oncol 2012: 928127.
47. Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K (2009) Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 69(19): 7507-7511.
48. Singhal A, Jie L, Kumar P, Hong GS, Leow MK, et al. (2014) Metformin as adjunct antituberculosis therapy. Sci Transl Med 6(263): 263ra159.
49. Esumi H, Lu J, Kurashima Y, Hanaoka T (2004) Antitumor activity of pyrviniumpamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol 3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation. Cancer Sci 95(8):685-690.
50. Lougheed KEA, Taylor DL, Osborne SA, Bryans JS, Buxton RS (2009) New Anti tuberculosis agents amongst known drugs Tuberculosis (Edinb) 89(5): 364-370.
51. Maitra A, Bates S, Kolvekar T, Devarajan PV, Guzman JD, et al. (2015) Repurposing -a ray of hope in tackling extensively drug resistance in tuberculosis. Int J Infect Dse 32: 50-55.
52. Livingston (1972) Virginia Wuerthele-Caspe. Cancer: a new breakthrough, Nash Publishing, Los Angeles, USA.
53. Ewing J (1919) Neoplastic diseases. 2nd (edn), WB Saunders, Philadelphia, USA, p. 1027.
54. Rusch HP (1985) The beginnings of cancer research centers in the United States. J Natl Cancer Inst 74(2): 391-403.
55. Hunter D (1978) The diseases of occupation. 6th (edn), Little Brown and Company, Boston, UK.
56. Fraenkel E, Much H (1910) Uber die Hodgkinsche Krankheit (Lymphomatosis granulomatosa), insbesondere derenAtiologie. Z Hyg 67: 159-200.
57. L’Esperance E (1931) Studies in Hodgkin’s disease. Annal Surg 93(1): 162-168.
58. Livingston V, Allen RM (1948) Presence of consistently recurring invasive mycobacterial forms in tumor cells. Microscop Soc Bull 2: 5-18.
59. Sweany HC (1926) Mutation forms of the tubercle bacillus. JAMA 87(15): 1206-1211.
60. Beinhauer LG, Mellon RR (1938) Pathogenesis of non-caseating epithelioid tuberculosis of hypoderm and lymph glands. Arch Dermatol Syph 37: 451-460.
61. Mellon RR, Fisher LW (1932) New studies on the filterability of pure cultures of the tubercle group of microorganisms. J Infect Dis 51(1):117-128.
62. Livingston V, Alexander-Jackson EA (1950) Cultural properties and pathogenicity of certain microorganisms observed from various proliferative and neoplastic diseases (published under Virginia Wuerthele-Caspe). Am J Med Sci 220: 636-648.
63. Boesch M (1960) The long search for the truth about cancer. GP Putnam’s Sons, New York, USA.
64. Glover T, Scott M (1926) A study of the Rous chicken sarcoma No.1. Can Lancet Practitioner 66(2): 49-62.
65. Goodman LS, Gilman A (1975) The pharmacologic basis of therapeutics. 5th (edn), MacMillan, New York, USA.
66. Skirvin JA, Relias V, Koeller J (1996) Long term sequelae of cancer chemotherapy. Highlights Oncol Practice 14(2): 26-34.
67. Pukkala E, Kyyronen P (2002) Tamoxifen and toremifene treatment of breast cancer and risk of subsequent endometrial cancer: a population based case-control study. Int J Cancer 100(3): 337-341.
68. Mankiewicz E (1965) Bacteriophages that lyse Mycobacteria andCorynebacteria and show cytopathogenic effect on tissue cultures of renal cells of Cercopithecus aethiops. Can Med Assn J 92: 31-33.
69. Dubos R (1987) The White Plague: Tuberculosis. New Brunswick, NJ: Man & Society; Rutgers University Press, USA, A Journal of History of Science 78: 615-616.
70. Aaronson JD (1926) Spontaneous tuberculosis in salt water fish. J Infect Dis 39(4): 315-320.
71. Wuerthele-Caspe VE, Alexander-Jackson E, Smith LW (1971) Some aspects of the microbiology of cancer. J Am Woman’s Med Assoc 8: 7.
72. Alexander-Jackson EA (1954) A specific type of microorganism isolated from animal and human cancer. Growth 18(1): 37-51.
73. Inoue S, Singer M (1970) Experiments on a spontaneously originated visceral tumor in the Newt Trituruspyrrhogaster. Annal NY AcadSci174(2): 729-764.
74. Lwoff A (1962) Biologic order. Karl Taylor Compton Lectures, Cambridge MA: The MIT Press, USA.
75. Klieneberger-Nobel E (1949) Origin, development and significance of L-forms in bacterial cultures. J Gen Microbiol 3: 434-442.
76. Rogers AD (1953) Erwin Frink Smith: a story of North American plant pathology. Philadelphia: American Philosophical Society 152(9): 879.
77. Seibert FB (1968) Pebbles on the Hill of a Scientist. In: Florence B (ed.), Seibert publisher, St. Petersburg, USA.
78. Cantwell A (1990) The cancer microbe. Aries Rising Press, USA.
79. Mattman LH (1993) Cell wall deficient forms-stealth pathogens. 2nd (edn), Boca Raton (ed.), CRC Press, USA.
80. Schneider B (1994) Specific binding of Bacillus Calmette-Guerinin urothelial tumor cells. In- vitro World J Urol 12(6): 337-344.
81. Rosenberg SA, Barry JM (1992) The transformed cell/unlocking the mysteries of cancer. GP Putnam’s Sons, New York, USA.
82. Devados PO, Klegerman ME, Groves MJ (1993) Phagocytosis of Mycobacterium bovis BCG organisms by murine S180 sarcoma cells. Cytobios 74(296): 49-58.
83. Moss RW (1997) The independent consumer’s guide to non-toxic treatment and prevention. Cancer therapy. Equinox Press, New York, USA.
84. Martin W (1997) Medical heroes and heretics. Old Greenwich, The Devin Adair Company, Connecticut, USA.
85. Acevedo H, Pardo M, Campbell-Acevedo E, Domingue GJ (1987) Human choriogonadotropin–like material in bacteria of different species: electron microscopy and immunocytochemical studies with monoclonal and polyclonal antibodies. J Gen Microbiol 133(3): 783-791.
86. (1990) Congress of the United States Office of Technology Assessment. Unconventional Cancer Treatments US Govt Printing Office, Washington, USA.
87. Glover TJ (1930) The bacteriology of cancer. Canada Lancet Mar 74(3): 92-111.
88. Mazet G (1941) Etude Bacteriologique sur la Maladie d’ Hodgkin. Montpellier Med, pp. 1-6.
89. Wuerthele-Caspe V (1949) Mycobacterial forms observed in tumors. J Am Med Womens Assoc 4: 135-141.
90. Alexander-Jackson E (1976) Progenitor Cryptocides, The Specific Pleomorphic Microorganism Isolated From Cancer. J Int Acad Metab 5: 31-39.
91. Alexander-Jackson E (1978) Microscopic and Submicroscopic Phases of P Cryptocides from Fresh Lymphocytic leukemia. J Int Acad Metab 1: 9-18.
92. Diller I, Diller W (1965) Intracellular acid-fast organisms isolated from malignant tissues. Trans Am Micr Soc 84: 138-148.
93. Diller I, Donnelly A, Fisher M (1967) Isolation of pleomorphic, acid- fast organisms from several strains of mice. Cancer Res 27(8): 1402-1408.
94. Seibert F, Feldmann F, Davis R, Richmond I (1970) Morphological, biological, and immunological studies on isolates from tumors and leukemic bloods. Ann N Y Acad Sci 174: 690-728.
95. Wang A, Xie J (1998) Infection of mycobacterium tuberculosis in lung cancer. Zhongguo Fei Ai ZaZhi 1(2): 92-94.
96. Xie J, Anchao W, Xiazhi Z (1999) Isolation of acid fast bacillus L- forms from carcinoma of Lung. Acta Academiae Medicinae Bengbu 24: 145-146.
97. Song LY, Yan WS, Zhao T (2002) Detection of in lung cancer tissue by indirect in situ nested PCR. Di Yi Jun Yi Da XueXueBao 22(11): 992-993.
98. Yesong WXQ, Lifa X (2004) A case report on pneumoconio tuberculosis complicated with lung cancer and Mycobacterium tuberculosis- L form infection. Chin J Industrial Med.
99. Zhang S, Guang-ling Z, Yan-sheng T (2009) Detection of Mycobacterium tuberculosis L forms infection in tissues of lung carcinoma. Chin J Public Health 25: 1317-1318.
100. Sheng TY, Kun CX, Tong H, Guang LH, Wei Z, et al. (2009) Study on the relationship between Mycobacterium tuberculosis L infection and lung cancer. Tumor 29(11): 1085-1089.
101. Tian Y, Hao T, Cao B, Zhang W, Ma Y, et al. (2015) Clinical End-Points Associated with Mycobacterium tuberculosis and Lung Cancer: Implications into Host-Pathogen Interaction and Coevolution. Bio Med Research Intern p. 9.
102. Alexander-Jackson E (1970) Ultraviolet spectrogramic microscope studies of Rous sarcoma virus cultured in cell-free medium. Ann N Y Acad Sci 174(2): 765-781.
103. Shinde SR, Chandawarkar RY, Deshmukh SP (1995) Tuberculosis of the breast masquerading as carcinoma: A study of 100 patients. World J Surg 19(3): 379-381.
104. Deng B, Huang W, Tan QY, Fan XQ, Jiang YG, et al. (2011) Breast cancer anti-estrogen resistance protein 1 (BCAR1/p130cas) in pulmonary disease tissue and serum. Mol Diagn Ther 15(1): 31-40.
105. Hatwal Deepa, Suri Vijay, Mishra Jai P, Joshi Chitra (2011) Tubercular mastitis is common in garhwal region of uttarakhand: clinico pathological features of 14 cases. Journal of Clinical and Diagnostic 5(8):1569-1573.
106. Lay G, Poquet Y, Salek-Peyron P, Puissegur MP, Botanch C, et al. (2007) Langhans giant cells from M tuberculosis-induced human granulomas cannot mediate mycobacterial uptake. J Pathol 211(1): 76-85.
107. Weiss MG, Sommerfeld J, Uplekar MW (2008) Social and cultural dimensions of gender and tuberculosis. Int J Tuberc Lung Dis 12(7):829-830.
108. Holmes CB, Hausler H, Nunn P (1998) A review of sex differences in the epidemiology of tuberculosis. Int J Tuberc Lung Dis 2(2): 96-104.
109. Tsuyuguchi K, Suzuki K, Matsumoto H, Tanaka E, Amitani R, et al. (2001) Effect of estrogen on Mycobacterium avium complex pulmonary infection in mice. Clin Exp Immunol 123(3): 428-434.
110. Havlik JA, Horsburgh CR, Metchock B, Williams PP, Fann SA, et al. (1992) Disseminated Mycobacterium avium complex infection: clinical identification and epidemiologic trends. J Infect Dis 165(3):577-580.
111. Tanaka E, Amitani R, Niimi A, Suzuki K, Murayama T, et al. (1997) Yield of computed tomography and bronchoscopy for the diagnosis of Mycobacterium avium complex pulmonary disease. Am J Respir Crit Care Med 155(6): 2041-2046.
112. Prince DS, Peterson DD, Steiner RM, Gottlieb JE, Scott R, et al. (1989) Infection with Mycobacterium avium complex in patients without predisposing conditions. N Engl J Med 321(13): 863-868.
113. Reich JM, Johnson RE (1991) Mycobacterium avium complex pulmonary disease. Am Rev Respir Dis 143(6): 1381-1385.
114. Howlader N, Noone AM, Krapcho M (2012) SEER Cancer Statistics Review, 1975-2009 (Vintage 2009 Populations). National Cancer Institute, Bethesda.
115. Philley JV, Kannan A, Griffith DE, Devine MS, Benwill JL, et al. (2017) Exosome secretome and mediated signaling in breast cancer patients with nontuberculous mycobacterial disease. Oncotarget 8(11): 18070-18081.
116. Cassidy PM, Hedberg K, Saulson A, Nelley Mc E, Winthrop KL (2009) Nontuberculous mycobacterial disease prevalence and risk factors: a changing epidemiology. Clin Infect Dis 49(12): e124-e129.
117. Franson JC, Friend M (1999) Field manual of wildlife diseases, Geological Survey, Washington DC, USA.
118. Miller RE, Fowler ME (2012) Fowler’s Zoo and Wild Animal Medicine Current Therapy, Volume 7. Elsevier Health Sciences, p. 688.
119. Phillips MS, von Reyn CF (2001) Nosocomial Infections Due to Nontuberculous Mycobacteria. Clin Infect Dis 33(8): 1363-1374.
120. Nason EN (1898) The Influence of Locality on the Prevalence of Malignant Disease. Br Med J 1(1941): 679-681.
121. Jones L (1899) The Influence of Locality on the Prevalence of Cancer. Br Med J 1(1996): 812-813.
122. Mason H (1902) A Possible Predisposing Cause of Cancer. Br Med J 1(2142): 139-141.
123. Miller BA, Gloeckler Ries LA, Hankey BF (1993) SEER cancer statistics review, 1973-1990. Bethesda, MD: National Institutes of Health.
124. Kulldorff M, Feuer EJ, Miller BA, Freedman LS (1997) Breast cancer clusters in Northeastern United States: a geographic analysis. Am J Epidemiol 146(2): 161-170.
125. Jenks S (1994) Researchers to comb Long Island for potential cancer factors. J Natl Cancer Inst 86: 88-95.
126. Lewis-Michi EL, Melius JM, Kallenbach LR (1996) Breast cancer risk and residence near industry or traffic in Nassau and Suffolk counties, Long Island, New York. Arch Environ Health 51: 255-265.
127. Wittenberg C (1994) Long Island breast cancer studies move forward. J Natl Cancer Inst 86: 1501-1503.
128. Jacquez GM, Greiling DA (2003) Local clustering in breast, lung and colorectal cancer in Long Island, New York. Int J Health Geogr 2(1): 3.
129. Gammon MD, Neugut AI, Santella RM, Teitelbaum SL, Britton JA, et al. (2002) The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Res Treat 74(3): 235-254.
130. Davidson A (1999) Oxford Companion to Food. Oxford: Oxford University Press, India, p. 593.
131. Zeng Y, Du J, Pu X, Yang J, Yang T, et al. (2015) Coevolution between Cancer Activities and Food Structure of Human Being from Southwest China. Bio Med Res Int 2015:497934.
132. (2009) Long Island Duck Farm History and Ecosystem Restoration Opportunities Report. US Army Corps of Engineers, New York District. Suffolk County, NY, pp. 1-20.
133. Davids HW, Cosulich WF (1968) Water Pollution from Duck Farms and Recent Developments in Treatment. 1968. Paper presented at the June 10, 1968 meeting of the New York Water Pollution Control Association, Montauk, NY, p. 9.
134. Partridge MS, Smith WG, Rutz DA (1992) Pest and Pesticide Use Assessment for Poultry Production Systems in New York State for 1998. Pesticide Management Education Program, Cornell University, USA.
135. World Health Organization (2008) Guidelines for Drinking water Quality, Incorporating 1st and 2nd Addenda, Volume 1, Recommendations. 3rd (edn), WHO, Geneva, Switzerland.
136. Fenwick A (2006) Waterborne Diseases-Could they be Consigned to History? Science 313: 1077-1081.
137. George I, Crop P, Servais P (2001) Use of β-D-Galactosidase and β-D-Glucuronidase Activities for Quantitative Detection of Total and Faecal Coliforms in Wastewater. Can J Microbiol 47(7): 670-675.
138. Shivaprasad HL, Palmieri C (2012) Pathology of mycobacteriosis in birds. Vet Clin North Am Exot Anim Pract 15(1): 41-55.
139. Song XH, Chen HX, Zhou WS, Wang JB, Liu MF, et al. (2016) Complete Genome Sequence of Mycobacterium avium, Isolated from Commercial Domestic Pekin Ducks (Anas platyrhynchos domestica), Determined Using PacBio Single-Molecule Real-Time Technology. Genome Announc 4(5).
140. (2003) Proceedings the U.S. EPA’s Research on Microorganisms in Drinking Water Workshop August 5-7, Cincinnati, Ohio.
141. Kids Count Data Center-a project of the Annie E. Casey Foundation, Maryland, United States.
142. Rosenzweig DY (1979) Pulmonary mycobacteria infections due to Mycobacterium avium complex. Clinical features and course in 100 consecutive patients. Chest 75: 115.
143. Wolinsky E (1979) Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis 119(1): 107-159.
144. Rosenzweig DY (1980) A typical mycobacteriosis. Clin Chest Med 1: 273-284.
145. Dlugovitzky D, Luchesi S (1995) Circulating immune complexes in patients with advanced tuberculosis and their association with autoantibodies and reduced CD4+ lymphocytes. Braz J Med Biol Res 28(3): 331-335.
146. Lamoureux G, Davignon L (1987) Is prior mycobacterial infection a common predisposing factor to AIDS in Haitians and Africans? Ann Inst Pasteur Immunol 138(4): 521-529.
147. Hirsch CS, Toossi Z (1999) Apoptosis and T-cell hyporesponsiveness in pulmonary tuberculosis. J Infect Dis 179(4): 945-953.
148. Chaouchi N, Arvanitakis L, Auffredou, Blanchard DA, Vazquez, et al. (1995) Characterization of transforming growth factor-B1 induced apoptosis in normal human B cells and lymphoma B cell lines. Oncogene 11(8): 1615-1622.
149. McDonald I, Wang H (1996) Transforming growth factor B1 cooperates with anti-immunoglobulin for the induction of apoptosis in group I (biopsy-like) Burkitt lymphoma cell lines. Blood 87: 1147-1154.
150. Fratazzi C, Arbeit RD, Carini C, Balcewicz-Sablinska MK, Keane J, et al. (1999) Macrophage apoptosis in mycobacterial infections. J Leukoc Biol 66(5): 763-764.
151. Molloy A, Laochumroonvorapong P, Kaplan G (1994) Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guerin. J Exp Med 180(4): 1499-1509.
152. Hirsch CS, Toossi Z, Johnson JL, Luzze H, Ntambi L, et al. (2001) Augmentation of apoptosis and interferon-γ production at sites of active Mycobacterium tuberculosis infection in human tuberculosis. J of Infectious Dis 183(5): 779-788.
153. Bermudez LE, Parker A, Petrofsky M (1999) Apoptosis of Mycobacterium avium-infected macrophages is mediated by both tumour necrosis factor TNF and Fas and involves the activation of caspases. Clin Exp Immunol 116(1): 94-99.
154. Edition of the Drinking Water Standards and Health Advisories (2012) Environmental Protection Agency, Office of Water, Washington, US, pp. 1-12.
155. Shin GA, Lee J, Freeman R, Cangelosi GA (2008) Inactivation of mycobacterium avium by UV irradiation. Appl Environ Microbiol 74(22): 7067-7069.
156. Pedley S, Bartram J, Cotruvo JA, Alfred D, Gareth Rb (2004) Pathogenic
mycobacteria in water: a guide to public health consequences, monitoring and management. World Health Organization, London pp. 144-168.
157. Nalbandian A, Yan BS, Pichugin A, Bronson RT, Kramnik I (2009) Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control. Oncogene 28(17): 1928-1938.
158. Da Silva AL, Bresciani MJ, Karnopp TE, Weber AF, Ellwanger JH, et al. (2015) DNA damage and cellular abnormalities in tuberculosis, lung cancer and chronic obstructive pulmonary disease. Multidiscip Respir Med, pp. 10-38.
159. Daley CL, Iseman M (2012) Mycobacterium avium complex and lung cancer: chicken or egg? Both? J Thorac Oncol 7(9): 1329-1330.
160. Lande L, Peterson DD, Gogoi R, Daum G, Stampler K, et al. (2012) Association between Pulmonary Mycobacterium Avium Complex Infection and Lung Cancer. J Thorac Oncol 7(9): 1345-1351.
161. Hosoda C, Hagiwara E, Shinohara T, Baba T, Nishihira R, et al. (2014) Clinical characteristics of pulmonary Mycobacterium avium complex infection complicated with lung cancer. Kekkaku 89(8): 691-695.
162. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, et al. (2007) An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 175(4): 367-416.
163. Bender F (1956) Primary pulmonary carcinoma associated with active pulmonary tuberculosis. Dis Chest 30(2): 207-216.
164. Moll A (1949) “Der Bronchialkrebs,” Medizinische Klinik. 44: 916.
165. Woodruff CE, Sen-Gupta N, Wallace S, Chapman PT, Martineau PC (1952) Anatomic Relationships between Bronchogenic Carcinoma and Calcified Nodulesin the Lung. Am Rev Tuberc 66(2): 151-160.
167. Sunnetcioglu A, Sunnetcioglu M, Binici I, Baran AI, Karahocagil MK, et al. (2015) Comparative analysis of pulmonary and extrapulmonary tuberculosis of 411 cases. Ann Clin Microbiol Antimicrob, pp. 14-34.
168. Ates Guler S, Bozkus F, Inci MF, Kokoglu OF, Ucmak H, et al. (2015) Evaluation of pulmonary and extrapulmonary tuberculosis in immunocompetent adults: a retrospective case series analysis. Med Princ Pract 24(1): 75-79.
169. Rasolofo Razanamparany V, Ménard D, Aurégan G, Gicquel B, Chanteau S (2002) Extrapulmonary and pulmonary tuberculosis in Antananarivo (madagascar): high clustering rate in female patients. J Clin Microbiol 40(11): 3964-3969.
170. Sreeramareddy CT, Panduru KV, Verma SC, Joshi HS, Bates MN (2008)
Comparison of pulmonary and extrapulmonary tuberculosis in Nepal- a hospital-based retrospective study. BMC Infect Dis p. 8.
171. Cooper A (1829) Diseases of the Breast-Part 1. S. McDowall Publisher, London, P. 73.
172. Audebert F, Schneidewind A, Hartmann P, Kullmann F, Schölmerich J (2006) Lymph node tuberculosis as primary manifestation of Hodgkin’s disease. Med Klin (Munich) 101(6): 500-504.
173. Centkowski P, Sawczuk-Chabin J, Prochorec M, Warzocha K (2005) Hodgkin’s lymphoma and tuberculosis coexistence in cervical lymph nodes. Leuk Lymphoma 46(3): 471-475.
174. Lamden K, Watson JM, Knerer G, Ryan MJ, Jenkins PA (1996) Opportunist mycobacteria in England and Wales: 1982 to 1984. Commun Dis Rep CDR Rev 6(11): 147-51.
175. Meissner G, Anz W (1977) Sources of Mycobacterium avium complex infection resulting in human disease. Am Rev Respir Dis 116(6):1057-1064.
176. Schaad UB, Votteler TP, McCracken GH, Nelson JD (1979) Management of atypical mycobacterial lymphadenitis in childhood: a review basedon 380 cases. J Pediatr 95(3): 356-360.
177. White MP, Bangash H, Goel K, Jenkins PA (1986) Nontuberculous mycobacterial lymphadenitis. Arch Dis Child 61(4): 368-371.
178. Felini M, Johnson E, Preacely N, Sarda V, Ndetan H, et al. (2011) Apilot Case-Cohort Study of Liver and Pancreatic Cancers in Poultry Workers. Ann Epidemiol 21(10): 755-766.
179. Johnson ES, Zhou Y, Lillian Yau C, Prabhakar D, Ndetan H, et al. (2010) Mortality from malignant diseases-update of the Baltimore union poultry cohort. Cancer Causes Control 21(2): 215-221.
180. Duesberg PH (1987) Retroviruses as carcinogens and pathogens: expectations and reality. Cancer Res 47(5): 1199-1220.
181. Demochowski L, Grey CE (1957) Subcellular Structures of Possible Viral Origin in Some Mammalian Tumors. Ann NY Acad Sci, pp. 559-615.
182. Miller JM, Miller LD, Olson C, Gillette KG (1969) Virus-like particles in phytohemagglutinin-stimulated lymphocyte cultures with reference to bovine lymphosarcoma. J Natl Cancer Inst 43(6): 1297-1305.
183. Seibert FB, Yeomans F, Baker JA, Davis RL, Diller IC (1972) Bacteria in
Tumors. Trans of the NY Acad of Sci June 34(6): 504-533.
184. Buehring GC, Shen HM, Jensen HM, Choi KY, Sun D, et al. (2014) Bovine leukemia virus DNA in human breast tissue. Emerg Infect Dis 20(5): 772-782.
185. Buehring GC, Shen HM, Jensen HM, Jin DL, Hudes M, et al. (2015) Exposure to Bovine Leukemia Virus is Associated with Breast Cancer: A Case-Control Study. PLoS One 10(9): e0134304.
186. Lysenko AP, Broxmeyer L, Vlasenko VV, Krasochko PA, Lemish AP, et al. (2016) Further Evidence for Cancer as a Cell-Wall-Deficient Mycobacterial Disease. J Mol Path Epidemol 1(1): 1-12.
187. Bittner JJ (1936) Some possible effects of nursing on the mammary gland tumor incidence of mice. Science 84(2172): 162.
188. Chauveau A. Transmission of virulent diseases by the ingestion of virulent principles in the digestive tract. Gaz de Paris p. 45.
189. Klebs E (1870) On the history of tuberculosis. Virchows Arch F path Anat, p. 291.
190. Gerlach AC (1870) On the inoculability of tuberculosis and theperilla, and on the transferability of the latter by feeding. Virchows Arch F path Anat 11: 297.
191. Pfeiffer DU (1994) The role of a wildlife reservoir in the epidemiology of bovine tuberculosis. New Zealand.
192. Dameshek W, Gunz (1965) Leukemia. Am J Med Sci 249: 115.
193. Latarjet R, Duplan JF (1962) Experiment and Discussion on Leukemogenesis by Cell-Free Extracts of Radiation-Induced Leukemia in Mice. Int J Rad Biol 5(4): 339-344.
194. Dobrindt U, Reidl J (2000) Pathogenicity islands and phage conversion: evolutionary aspects of bacterial pathogenesis. Int J Med Microbiol 290: 519-527.
195. Landman OE, Burchard WK, Angelety LH (1962) Lysogeny and bacteriophage adsorption in stable and reverting L-forms of Salmonella paratyphi B and Escherichia coli. Bacteriol Proc, p. 53.
196. Nelson EL, Pickett MJ (1951) The Recovery of L Forms of Brucella and their Relation to Brucella Phage. J Infect Dis 89(3): 226-232.
197. Kruegar AP, Cohn T, Smith PN, McGuire CD (1948) Observations on the effect of penicillin on the reaction between phage and staphylococc. J Gen Physiol 31: 477-488.
198. Takahashi S (1979) L phase growth of Mycobacteria. Cell wall deficient form of Mycobacteria. Kekkaku 54: 63-70.
199. Broxmeyer L, Sosnowska D, Miltner E, Chacón O, Wagner D, et al. (2002) Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent mycobacterium: a model for phage therapy of intracellular bacterial pathogens. J Infect Dis 186(8): 1155-1160.
200. Halsted WS (1912) W.W. Duke to Halsted. In: William Stewart Halsted papers, Series I. The Alan Mason Chesney Medical Archives of the Johns Hopkins Medical Institutions, Baltimore, USA.

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